Lutris

Lutris uses scripts to automatically setup wine prefixes with all the quirks it needs. If your application has a script available, then you're in luck! If not, you can use wine to install the application manually then add it to your Lutris library.

Add custom runners (manually)

You can download and unzip your wine/proton fork to the following folder

$HOME/.local/share/lutris/runners/
├── proton
│   ├── ge-proton
│   │   ├── compatibilitytool.vdf
│   │   ├── filelock.py
│   │   ├── files
│   │   ├── LICENSE
│   │   ├── LICENSE.OFL
│   │   ├── PATENTS.AV1
│   │   ├── proton
│   │   ├── proton_3.7_tracked_files
│   │   ├── protonfixes
│   │   ├── __pycache__
│   │   ├── toolmanifest.vdf
│   │   ├── user_settings.sample.py
│   │   └── version
└── wine
    └── wine-ge-8-26-x86_64
        ├── bin
        ├── lib
        ├── lib64
        └── share

It should become available as an option in the runners menu.